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Research and Development

Research & Development

Translating basic research and technological
advances into clinically valuable and commercially
viable tools that improve health

Overview

The Research and Development division at SRL firmly reinforces the mission and strategy of the organization through its translational and multidisciplinary research initiatives The goal of translational research is to advance basic research and technological innovations for accurate diagnosis, appropriate treatment and efficient patient care.

To achieve this goal, SRL's R&D division:

  • Develops new tests, translates emerging diagnostic concepts and fosters absorption of cutting edge technologies in the field of clinical diagnostics
  • Expands the existing horizon of Clinical Diagnostics from screening, diagnosis and monitoring to advanced areas such as predisposition, preventive and targeted medicine
  • Creates sound knowledge base by promoting and championing translational research
  • Encourages dissemination and integration of research knowledge into medical practices
  • Collaborates with National and International organizations for conducting applied research to establish innovative and cost-effective diagnostic solutions

R & D Activities:

Evidenced by noteworthy achievements, R&D division has come a long way since its inception. Latest innovations, technologies and advanced concepts fueled our research activities to identify and evaluate their true potential for the benefit of clinicians and patients.

  • New Assay Development
  • New Technology Evaluation
  • Validation
  • Knowledge Management
  • Contract Research (Clinical and Bio-technological)
  • R&D Services in the field of Genomics and Proteomics

Education and Training

Our constant research focus enables us to gain knowledge and disseminate our learning through Education and Training thereby enhancing value-added services to all our customers.

Knowledge is undoubtedly the worst enemy of disease. Advancements in diagnostics are rapidly evolving, thereby posing challenge to the clinicians to keep pace with fast-moving innovations and knowledge in this field. We believe promoting greater access to education and training particularly in the field of advanced diagnostics is important because of the crucial role it plays in enhancing patient care and management.

Taking forward the fact that professional development is essential for the growth of organizations as well as individuals, the R&D division aims to sustain the culture of Continuing Education (CE) among the scientific staff. This is done with a view to increasing awareness and updating knowledge related to recent developments in the field of clinical diagnostics and disease management through the Knowledge Management team. As a component of the Continuing Education Program, the R&D also coordinates Continued Medical Education (CME) programs for clinicians to increase awareness about advances in diagnostics and its impact on the management of health conditions.

The R&D division at SRL is intensely involved in the training process of the sales force with the aim of equipping them with precise knowledge of new advancements.

Education

Academic courses
  • PhD in Biotechnology (affiliated with University of Mumbai)
  • Fellowship in Molecular Pathology (recognized by Maharashtra University of Health Sciences)
  • MSc in Biotechnology (by research) (affiliated with University of Mumbai)

Training

Research Training
  • Short Term (1-3 months)
  • Long Term (3-6 months)
Sales Training
  • Basic Sales Training for New Recruits
  • Refresher courses
  • Advanced Courses for Product Specialists
Professional Training
  • 3-month full time training programme in Molecular Pathology for doctors (MD in Pathology/Microbiology/Biochemistry)
  • Call +91-22-67801208 for further details.

Publications

Scientific publications are important to us; they enable us to collaborate and share ideas with, as well as learn from, the broader scientific community. All our research work is underpinned by a solid evidence base. Throughout the year we undertake clinical studies, projects, support research in universities and publish data on pertinent health issues to ensure that we are leading the way in evidence and data on clinical diagnostics in India. Below are our most recent publications.

 
Our latest publications (2015-2017)
  • Bhandari P, Ahmad F, Das BR. (2017) Molecular profiling of gene copy number abnormalities in key regulatory genes in high-risk B-lineage acute lymphoblastic leukemia: frequency and their association with clinicopathological findings in Indian patients. Med Oncol. 2017 May; 34(5):92.
  • Bhandari P, Ahmad F, Mandava S, Das BR. (2016) Association of Genetic Variants in ARID5B, IKZF1 and CEBPE with Risk of Childhood de novo B-Lineage Acute Lymphoblastic Leukemia in India. Asian Pac J Cancer Prev. 2016; 17(8):3989-95.                                                            
  • Bhaumik, S., Ahmad, F. & Das, B.R. Somatic Mutation Analysis of KRAS, BRAF, HER2 and PTEN in EGFR mutation negative non-small cell lung carcinoma: Determination of frequency, distribution pattern and identification of novel deletion in HER2 gene from Indian Patients. Med Oncol. 2016 Oct; 33(10):117.
  • Gandra S, Mojica N, Klein EY, Ashok A, Nerurkar V, Kumari M, Ramesh U, Dey S, Vadwai V, Das BR, Laxminarayan R. (2016) Trends in antibiotic resistance among major bacterial pathogens isolated from blood cultures tested at a large private laboratory network in India, 2008-2014. Int J Infect Dis. 2016 Sep; 50:75-82
  • Naik S, Das BR (2016) New WHO Guidelines: Implications on The rapeutics and Monitoring of HIV Infections. HIV Curr Res 1: 102. doi:10.4172/hicr.1000102.
  • Bhanushali A, Nair A, Jagdale G, Suvarna T, Das BR. Association of Genetic Variants at the 4q25 Locus with Atrial Fibrillation in Indian Population. J Clin Lab Anal. Epub 2016 Jun 27. doi: 10.1002/jcla.22017.
  • Ahmad F, Badwe A, Verma G, Bhatia S, Das BR. Molecular evaluation of PIK3CA gene mutation in breast cancer: determination of frequency, distribution pattern and its association with clinicopathological findings in Indian patients. (2016) Med Oncol. 2016 Jul;33(7):74. doi: 10.1007/s12032-016-0788-y. Epub 2016 Jun 9.
  • Bhanushali AA, Mandsaurwala A, Das BR. Homozygous c.1160C>T (P38L) in the MECP2 gene in a female Rett syndrome patient. (2016) J Clin Neurosci. 2016 Mar; 25:127-9. doi: 10.1016/j.jocn.2015.08.040. Epub 2016 Jan 2.                                                                                                                                                                                           
  • Vadwai V, Mandsaurwala A, Mukherjee S, Suchi Vora, Das BR* CCR5 Genotyping and Chemokine Receptor usage among HIV-1 Treatment - Naive and Experienced Patients in India. (2015) Int J AIDS Res. 02(5), 43-45.
  • Viral Vadwai, Vidya Nerurkar, Mamta Kumari, Uma Ramesh, Sunanda Dey and Bibhu Ranjan Das. Antimicrobial Resistance Pattern among Community-Acquired Gram-Positive and Gram-Negative Bacterial Bloodstream Isolates in India. Annals of Clinical and Laboratory Research ISSN 2386-5180 – 2015; 3(2:10):1-13.
  • Bhandari P, Ahmad F, Dalvi R, Koppaka N, Kokate P, Das BR, Mandava S. Cytogenetic Profile of De Novo B lineage Acute Lymphoblastic Leukemia: Determination of Frequency, Distribution Pattern and Identification of Rare and Novel Chromosomal Aberrations in Indian Patients. Asian Pac J Cancer Prev. 2015;16(16):7219-29.
  • Ahmad F, Lad P, Bhatia S, Das BR. Molecular spectrum of c-KIT and PDGFRA gene mutations in gastro intestinal stromal tumor: determination of frequency, distribution pattern and identification of novel mutations in Indian patients. Med Oncol. 2015 Jan;32(1):424.
  • Das BR, Bhaumik S, Ahmad F, Mandsaurwala A, Satam H. Molecular Spectrum of Somatic EGFR and KRAS Gene Mutations in non Small Cell Lung Carcinoma: Determination of Frequency, Distribution Pattern and Identification of Novel Variations in Indian Patients. Pathol Oncol Res. 2015 Jul; 21(3):675-87. doi: 10.1007/s12253-014-9874-7. Epub 2015 Jan 31.
  • Das BR, Roy A, Khan FR. Cartilage oligomeric matrix protein in monitoring and prognostication of osteoarthritis and its utility in drug development. Perspect Clin Res. 2015 Jan-Mar;6(1):4-9. doi: 10.4103/2229-3485.148792. Review.
  • Aparna Bhanushali Pradip K Patra, Smarnika Pradhan, Suraj Khanka, Sujata Singh; Das BR. Genetics of fetal hemoglobin in Tribal Indian patients with sickle cell anemia. Translational Research 2015 Jun;165(6):696-703. doi: 10.1016/j.trsl.2015.01.002.
  • Bhanushali AA, Patra PK, Nair D, Verma H, Das BR. Genetic variant in the BCL11A (rs1427407), but not HBS1-MYB (rs6934903) loci associate with fetal hemoglobin levels in Indian sickle cell disease patients. Blood Cells Mol Dis. 2015 Jan; 54(1):4-8. doi: 10.1016/j.bcmd.2014.10.003.

Communiques

communiques

We believe effective communication is the foundation for strong and trusting relationship. The benefit of effective communication with clinicians and patients are far-reaching; they aid in bridging the gap between latest advancements, knowledge and action. Understanding this need, our knowledge management team is actively involved in creating and sustaining the tools for continuous knowledge dissemination through focused literary research. As part of these initiatives, a monthly newsletter, an email detailer and a semi-annual newsletter are prepared and circulated.

Innersense

The newsletter focuses on various disease segments and highlights the new concepts and diagnostic modalities. It also provides an overview of improvement and upgradation of technology and applications, emerging therapeutic strategies and significant research findings on the international front.

View Latest Issue

MediMail

The e-mail detailer focuses on in-depth information relating to sensitivity, specificity, technological advantages, clinical utility and other aspects of diagnostic, prognostic or monitoring tools.

View Latest Issue

Pulse

This biannual newsletter is designed to give its readers a glimpse of notable research and development activities of various departments of SRL, few interesting healthcare related facts and update the customers on the latest scientific activities including publications from SRL.

View Latest Issue

Recognitions

Our recognitions outline our commitment for research and knowledge excellence.
  • Department of Scientific & Industrial Research (DSIR), Government of India recognized in-house R&D unit
  • ISO 9001: 2008 certification
  • Recognized by University of Mumbai as a Centre for Post Graduate Research (MSc & PhD)
  • Association with BCIL (Biotech Consortium India Ltd) for conducting Biotech Industrial Training Programme (BITP)
  • Recognition by MUHS for Fellowship in Molecular Pathology for post graduate doctors